Listed below are the interest group ListServ lists currently available on the PBRC NORC ListServ. These lists are part of an effort to stimulate the development of ideas and projects within the research areas addressed by the NORC. Participants are encouraged to post messages that will become effective stimuli for discussion.
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subscribe <list name>
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*Please note that these lists were created for Pennington Biomedical Research Center NORC members. Membership in the NORC is required to participate in any of the interest groups. A doctoral degree is required for membership in the NORC.
PBRC NORC ListServ Interest Groups
Subscribe to the NORC-EGNP-L interest group.
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This list is concerned with nutritional programming and its potential role in the etiology of chronic disease. While the term "nutritional programming" is being used, and indeed, has become a buzz word, it is remarkable how little we really understand about the phenomenon. Presumably, it refers to the influence of the environment upon epigenetic modification of the genome in a manner that affects the expression genes associated with energy balance, that is, in the case where the environmental input leads to changes in energy balance and obesity. However, the number of areas of physiology, development and disease that will result in individual quantitative variation in phenotypes will be huge. Some topics could include (but certainly should not be limited to): What are some simple model systems? What are the phenotypes? What kind of environmental variables initiate the emergence of an epigenetic phenotype? How do you identify the epigenetic markers? How do you determine the modes of its transmission? Is there a genetic basis to epigenetic inheritance? In other words are certain genontypes more poised to respond epigenetically? Is this good or bad? What kind of epigenetic modifications could be an physiologically advantageous? Can simple cell culture models be developed? What are the molecular methods that can most efficiently identify epigenetic changes? While a regular seminar could be formed to discuss epigenetics and nutritional programming, this open chat room forum could be more effective approach since it has the advantage that a contribution can be made by anyone, from anywhere and at anytime. I hope that participants feel free to post new controversial papers that become published as stimuli for discussion. As time goes by and we develop some experience with this forum, perhaps searchable archives of papers and discussion can be established.